Cation Permeability and Cation-Anion Interactions in a Mutant GABA-Gated Chloride Channel from Drosophila
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Anion and cation permeability of a chloride channel in rat hippocampal neurons
The ionic permeability of a voltage-dependent Cl channel of rat hippocampal neurons was studied with the patch-clamp method. The unitary conductance of this channel was approximately 30 pS in symmetrical 150 mM NaCl saline. Reversal potentials interpreted in terms of the Goldman-Hodgkin-Katz voltage equation indicate a Cl:Na permeability ratio of approximately 5:1 for conditions where there is ...
متن کاملAnion and Cation Permeability of a Chloride Channel in Rat Hippocampal Neurons
I N T R O D U C T I O N This article examines the ionic selectivity o f an anion channel that is consistently found in the somatic membran e o f hippocampal neurons f rom embryonic rats. Characteristic o f the channel is a relatively small unitary conductance (~30 pS in symmetrical 150 mM NaCI saline) that is tu rned on and of f by a weakly voltage-dependent , kinetically complex gating process...
متن کاملCation-cation and anion-anion complexes stabilized by halogen bonds.
Stable minima showing halogen bonds between charged molecules with the same sign have been explored by means of theoretical calculations. The dissociation transition states and their corresponding barriers have also been characterized. In all cases, the results indicate that the complexes are thermodynamically unstable but kinetically stable with respect to the isolated monomers in gas phase. A...
متن کاملNa+-gated nonselective cation channel from lobster olfactory projection neurons.
Na+-gated nonselective cation channel from lobster olfactory projection neurons. J. Neurophysiol. 80: 3387-3391, 1998. A nonselective cation channel specifically activated by intracellular Na+ was identified in cell-free patches taken from cultured lobster olfactory projection neurons. Na+ reversibly activates the channel in a concentration-dependent manner, with a "half-effect" Na+ concentrati...
متن کاملAnion-cation interactions in the pore of neuronal background chloride channels
Background Cl channels in neurons and skeletal muscle are significantly permeable for alkali cations when tested with asymmetrical concentrations of the same salt. Both anion and cation permeation were proposed to require binding of an alkali cation with the pore (Franciolini, F., and W. Nonner. 1987. Journal of General Physiology. 90:453-478). We tested this hypothesis by bilaterally substitut...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1999
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(99)76924-9